At its core, my research is focused on understanding the molecular regulatory programs underlying normal cortical development and cortical function. As a result, my research project is intrinsically interdisciplinary, spanning the fields of molecular biology, developmental biology, neuroscience, and behavioral sciences, and initiating extensive collaborations both within and between departments is necessary to answer the questions at the heart of my project. In addition to the broad range of approaches I am employing, a key resource at my disposal is a conditional knockout mouse line, in which I can target a minor spliceosome component for removal in specific tissues. Using this mouse line, I can separately parse out how minor splicing informs cortical development, and how this altered development impacts cortical function, and how minor splicing regulates the function of mature neurons. Subsequent use of comprehensive behavioral testing paradigms can then be used to elucidate whether the functions of specific cortical regions/circuits, such as those underlying attention and motor activity, are differentially sensitive to shifts in minor splicing-controlled gene expression.